Digital signal processing for microphone partial occlusion detection is described. In one embodiment, an electronic system for audio noise processing and for noise reduction, using a plurality of microphones, includes a first noise estimator to process a first audio signal from a first one of the microphones, and generate a first noise estimate. The electronic system also includes a second noise estimator to process the first audio signal, and a second audio signal from a second one of the microphones, in parallel with the first noise estimator, and generate a second noise estimate. A microphone partial occlusion detector determines a low frequency band separation of the first and second audio signals and a high frequency band separation of the first and second audio signals to generate a microphone partial occlusion function that indicates whether one of the microphones is partially occluded.