A single-item-access (SIA) sub-drawer is disclosed that has a body with a compartment and a lid that is selectably securable in a closed position that encloses the compartment. The SIA sub-drawer includes a lid latch configured to secure and selectably release the lid and a sub-drawer latch configured to engage and selectably release a retention hook to secure the SIA sub-drawer to a dispensing cabinet. The SIA sub-drawer also includes a processor configured to cause the lid latch to release the lid upon receipt of a lid release signal and to cause the sub-drawer latch to release the retention hook upon receipt of a sub-drawer release signal.