发明申请
- 专利标题： ANTIGENIC PEPTIDE OF HSV-2 AND METHODS FOR USING SAME
- 专利标题（中）： HSV-2的抗原肽及其使用方法
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申请号： US14727666申请日： 2015-06-01
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公开(公告)号： US20150335734A1公开(公告)日： 2015-11-26
- 发明人: Lawrence Corey , Kerry J. Laing , Anna Wald , David M. Koelle
- 申请人： University of Washington , Fred Hutchinson Cancer Research Center
- 申请人地址： US WA Seattle US WA Seattle
- 专利权人： FRED HUTCHINSON CANCER RESEARCH CENTER,UNIVERSITY OF WASHINGTON
- 当前专利权人： FRED HUTCHINSON CANCER RESEARCH CENTER,UNIVERSITY OF WASHINGTON
- 当前专利权人地址： US WA Seattle US WA Seattle
- 主分类号： A61K39/245
- IPC分类号： A61K39/245 ; C12N7/00
摘要：
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection, including epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
公开/授权文献
- US09579376B2 Antigenic peptide of HSV-2 and methods for using same 公开/授权日：2017-02-28
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