A system and method for additive manufacturing of heterogeneous porous structures, and structures made therefrom. The system includes: a powder feeding module for depositing layers of powder material; a binder module for dispensing powder binding material; a porogen module for selectively depositing at least one porogen to the layers of powder material, wherein the at least one porogen is removable to produce at least one predetermined porosity in the part; and a controller to control the powder feeding module, binder module and porogen module. The method includes: forming a layer by performing at least one of: applying a powder to a substrate; applying a binder to the powder; applying at least one porogen to the powder based on a predetermined pattern; and forming additional layers until a predetermined number of layers is reached, wherein at least one of the layers includes a porogen.