发明申请
US20150353563A1 PYRAZOLO[3,4-D]PYRIMIDINONE COMPOUNDS AS INHIBITORS OF THE P53/MDM2 INTERACTION
有权
作为P53 / MDM2相互作用的抑制剂的吡唑并[3,4-D]嘧啶酮化合物
![PYRAZOLO[3,4-D]PYRIMIDINONE COMPOUNDS AS INHIBITORS OF THE P53/MDM2 INTERACTION](/docs/US/2015-12-10/US20150353563A1/abs.jpg.600x600.jpg)
- 专利标题： PYRAZOLO[3,4-D]PYRIMIDINONE COMPOUNDS AS INHIBITORS OF THE P53/MDM2 INTERACTION
- 专利标题（中）： 作为P53 / MDM2相互作用的抑制剂的吡唑并[3,4-D]嘧啶酮化合物
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申请号： US14762051申请日： 2014-01-21
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公开(公告)号： US20150353563A1公开(公告)日： 2015-12-10
- 发明人: Pascal FURET , Vito GUAGNANO , Philipp HOLZER , Joerg KALLEN , Robert MAH , Keiichi MASUYA , Achim SCHLAPBACH , Andrea VAUPEL
- 申请人： Pascal FURET , Vito GUAGNANO , Philipp HOLZER , Joerg KALLEN , Robert MAH , Keiichi MASUYA , Achim SCHLAPBACH , Andrea VAUPEL
- 国际申请： PCT/IB2014/058442 WO 20140121
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/519
![PYRAZOLO[3,4-D]PYRIMIDINONE COMPOUNDS AS INHIBITORS OF THE P53/MDM2 INTERACTION](/abs-image/US/2015/12/10/US20150353563A1/abs.jpg.150x150.jpg)
摘要：
The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.