发明申请
- 专利标题： STABILIZED STAT3 DECOY OLIGONUCLEOTIDES AND USES THEREFORE
- 专利标题（中）： 稳定的STAT3分解寡核苷酸及其用途
-
申请号： US14739990申请日： 2015-06-15
-
公开(公告)号： US20150353613A1公开(公告)日： 2015-12-10
- 发明人: JENNIFER R. GRANDIS , Daniel Johnson , Danith Ly
- 申请人： JENNIFER R. GRANDIS , Daniel Johnson , Danith Ly
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; A61K45/06 ; A61K39/395 ; A61K31/713
摘要：
The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically. The invention is also based on pharmaceutical compositions comprising these unimolecular decoys, and methods for using these decoys in the treatment of cancer.