- 专利标题： COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY
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申请号： US14772295申请日： 2014-02-27
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公开(公告)号： US20160009689A1公开(公告)日： 2016-01-14
- 发明人: Michael Miller , Kallol Basu , Duane DeMong , Jack Scott , Wei Li , Andrew Stamford , Marc Poirer , Paul Tempest
- 申请人： Michael MILLER , Kallol BASU , Duane DEMONG , Jack SCOTT , Wei LI , Andrew STAMFORD , Marc POIRIER , Paul TEMPEST , MERCK SHARP & DOHME CORP.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 优先权： CNPCTCN2013/072130 20130304
- 国际申请： PCT/US2014/018888 WO 20140227
- 主分类号： C07D403/04
- IPC分类号： C07D403/04 ; C07D413/14 ; C07D401/14 ; C07D471/10 ; C07D491/107 ; C07D498/10 ; C07D487/10 ; C07D405/14 ; C07D498/04 ; C07D487/04 ; C07D409/14 ; C07D403/14 ; C07D498/08
摘要：
The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.