A luggage case with two zipper pockets includes a case body, a first zipper pocket and a second zipper pocket. The case body includes a datum plane located at on an outer surface thereof and is provided with an inner storage space sealed with a case-body zipper. The first zipper pocket is connected to and opened or closed with respect to the datum plane by a first zipper. The second zipper pocket is connected to and opened or closed with respect to the outer surface of the case body by a second zipper. The first and second zipper pockets are located at the same side of the case body, the first and second zippers are located at different heights with respect to the datum plane, so as to prevent interference of the two zippers when they move to the boundary between the two zipper pockets.