发明申请
US20160031859A1 Alkyl [(S)-1-((S)-2--buta-1,3-diynyl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamate naphthalene-1,5-disulfonate, pharmaceutical composition, medicament, method for treatment of viral diseases
审中-公开
- [（S）-1 - （（S）-2-丁-1,3-二炔基） - 苯基] -1H-咪唑-2-基} - 吡咯烷-1-羰基）-2-甲基 - 丙基] - 氨基甲酸萘-1,5-二磺酸盐，药物组合物，药物，治疗病毒性疾病的方法
![Alkyl [(S)-1-((S)-2--buta-1,3-diynyl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamate naphthalene-1,5-disulfonate, pharmaceutical composition, medicament, method for treatment of viral diseases](/docs/US/2016-02-04/US20160031859A1/abs.jpg.600x600.jpg)
- 专利标题： Alkyl [(S)-1-((S)-2--buta-1,3-diynyl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamate naphthalene-1,5-disulfonate, pharmaceutical composition, medicament, method for treatment of viral diseases
- 专利标题（中）： - [（S）-1 - （（S）-2-丁-1,3-二炔基） - 苯基] -1H-咪唑-2-基} - 吡咯烷-1-羰基）-2-甲基 - 丙基] - 氨基甲酸萘-1,5-二磺酸盐，药物组合物，药物，治疗病毒性疾病的方法
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申请号： US14798541申请日： 2014-02-04
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公开(公告)号： US20160031859A1公开(公告)日： 2016-02-04
- 发明人: Alexandre Vasilievich Ivachtchenko
- 申请人： Andrey Alexandrovich IVASHCHENKO , Nikolay Filippovich SAVCHUK , Alexandre Vasilievich IVACHTCHENKO
- 优先权： RU2013105163 20130207
- 国际申请： PCT/RU2014/000079 WO 20140204
- 主分类号： C07D403/14
- IPC分类号： C07D403/14
![Alkyl [(S)-1-((S)-2--buta-1,3-diynyl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamate naphthalene-1,5-disulfonate, pharmaceutical composition, medicament, method for treatment of viral diseases](/abs-image/US/2016/02/04/US20160031859A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to NS5A inhibitors, to novel pharmaceutical composition, antiviral medicament, method for prophylaxis and treatment of viral diseases, in particular caused by hepatitis C (HCV) virus and hepatitis GBV-C virus.Alkyl [(S)-1-((S)-2-{5-[4-(4-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3 H-imidazol-4-yl}-buta-1,3-diynyl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamate naphthaline-1,5-disulfonate of the general formula 1, possibly in crystalline or polycrystalline form, have been proposed, wherein: R is C1-C3 alkyl.
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