A method, system, and computer program product for minimizing intra-cell and inter-cell interference in a multi-cell full duplex communication system in a wireless network. The method includes selecting, by a clint selector, a plurality of clients, wherein the plurality of clients includes a plurality of uplink clients configured to transmit signals and a plurality of downlink clients configured to receive signals over a plurality of data streams in each cell of the multi-cell full duplex communication system, and performing, by a spatial interference aligner, spatial interference alignment on interfering data streams to align the interfering data streams of uplink clients towards downlink clients in its own cell and downlink clients in a neighboring cell.