A quick release device for at least partially muscle-powered two-wheeled vehicles such as bicycles, having an axle unit and a clamping mechanism. The axle unit includes an axle extending axially, a locking means at a first end of the axle unit and a fastener at a second end of the axle unit. The clamping mechanism is suitable for mounting and demounting the axle unit to a two-wheeled vehicle. The clamping mechanism includes an operating lever and a clamping component connected therewith. The clamping component can be non-rotatably coupled with the axle unit and can be decoupled from the axle unit. The operating lever of the clamping mechanism can be moved from an engagement position in which it is non-rotatably connected with the clamping component to a rotary position in which it is freely rotatable relative to the clamping component, while the clamping component is non-rotatably coupled with the axle unit.