发明申请
US20160060236A1 PKC-ACTIVATING COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
审中-公开
用于治疗神经损伤性疾病的PKC-活化化合物
- 专利标题： PKC-ACTIVATING COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
- 专利标题（中）： 用于治疗神经损伤性疾病的PKC-活化化合物
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申请号： US14803762申请日： 2015-07-20
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公开(公告)号： US20160060236A1公开(公告)日： 2016-03-03
- 发明人: Thomas J. NELSON , Daniel L. ALKON
- 申请人： Blanchette Rockefeller Neurosciences Institute
- 申请人地址： US WV Morgantown
- 专利权人： Blanchette Rockefeller Neurosciences Institute
- 当前专利权人： Blanchette Rockefeller Neurosciences Institute
- 当前专利权人地址： US WV Morgantown
- 主分类号： C07D303/42
- IPC分类号： C07D303/42 ; C07C31/13 ; C12N9/12 ; C07C53/134 ; C07D303/40 ; C07C69/608 ; C07C31/133
摘要：
The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.