发明申请
US20160060255A1 THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS
有权
噻唑替代氨基酸作为分离型酪氨酸激酶抑制剂
- 专利标题： THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS
- 专利标题（中）： 噻唑替代氨基酸作为分离型酪氨酸激酶抑制剂
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申请号： US14786464申请日： 2014-04-22
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公开(公告)号： US20160060255A1公开(公告)日： 2016-03-03
- 发明人: Neville J. Anthony , Brian M. Andresen , Alan B. Northrup , Kaleen K. Childers , Anthony Donofrio , Thomas A. Miller , Yuan Liu , Michelle R. Machacek , Hyun Chong Woo , Kerrie B. Spencer , John Michael Ellis , Michael D. Altman , Eric T. Romeo , Daniel Guay , Jonathan Grimm , Marie-Eve Lebrun , Joel S. Robichaud , Liping Wang , Byron DuBois , Qiaolin Deng
- 申请人： Neville J. ANTHONY , Brain M. ANDERSEN , Alan B. NORTHRUP , Kaleen K. CHILDERS , Anthony FRIO , Thomas A. MILLER , Yuan LIU , Michelle R. MACHACEK , Hyun Chong WOO , Kerrie B. SPENCER , John Michael ELLIS , Micheal D. ALTMAN , Eric T. ROMEO , Daniel GUAY , Jonathan GRIMM , Marie-Eve LEBRUN , Joel S. ROBICHAUD , Liping WANG , Byron DUBOIS , Qiaolin DENG , MERICK SHARP & DOHNE CORP. , MERCK CANADA INC.
- 申请人地址： CA QC Kirkland US NJ Rahway
- 专利权人： Merck Canada Inc.,Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Canada Inc.,Merck Sharp & Dohme Corp.
- 当前专利权人地址： CA QC Kirkland US NJ Rahway
- 国际申请： PCT/US2014/034909 WO 20140422
- 主分类号： C07D417/14
- IPC分类号： C07D417/14 ; A61K31/53 ; A61K31/4439 ; A61K31/501 ; A61K31/506 ; A61K31/497
摘要：
The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, and R4 are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).