发明申请
- 专利标题： QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
- 专利标题（中）： 喹啉胺M1受体阳性单独调节剂
-
申请号： US14945005申请日： 2015-11-18
-
公开(公告)号： US20160075656A1公开(公告)日： 2016-03-17
- 发明人: Scott D. Kuduk , Kelly- Ann S. Schlegel , Zhi-Qiang Yang
- 申请人： MERCK SHARP & DOHME CORP.
- 申请人地址： US NJ Rahway
- 专利权人： MERCK SHARP & DOHME CORP.
- 当前专利权人： MERCK SHARP & DOHME CORP.
- 当前专利权人地址： US NJ Rahway
- 主分类号： C07D215/60
- IPC分类号： C07D215/60 ; C07D401/14 ; C07D405/14 ; C07D215/48 ; C07D471/04 ; C07D409/14 ; C07D417/14 ; C07D413/14 ; C07D401/10 ; C07D405/12 ; C07D401/06 ; C07D413/06
摘要：
The present invention is directed to quinoline amide compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositious comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.