发明申请
- 专利标题: Antibacterial Biaromatic Derivatives
- 专利标题(中): 抗菌双酚衍生物
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申请号: US14784602申请日: 2014-04-15
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公开(公告)号: US20160075722A1公开(公告)日: 2016-03-17
- 发明人: Sylvaine CREN , Astrid FRIEDLI , Christian HUBSCHWERLEN , Georg RUEEDI , Cornelia ZUMBRUNN
- 申请人: ACTELION PHARMACEUTICALS LTD
- 优先权: IBPCT/IB2013/053021 20130416
- 国际申请: PCT/IB2014/060724 WO 20140415
- 主分类号: C07D513/04
- IPC分类号: C07D513/04 ; C07D413/04 ; C07D417/14 ; C07D413/14 ; C07D417/04 ; C07D498/04
摘要:
The invention relates to antibacterial compounds of formula I (I) wherein R is H, cyano, alkoxy, cyanomethoxy, cycloalkylmethoxy, hydroxyalkoxy, alkoxyalkoxy, alkoxycarbonyl, 2-ethoxy-2-oxoethoxy, 2-(methylamino)-2-oxoethoxy, (1-cyanocyclobutyl)methoxy, 3-hydroxy-pyrrolidin-1-yl or 3,4-dihydroxycyclopentyl)methoxy; U1 is N or CR1, U2 is N or CR1, U3 is N or CR3 and U4 is N or CR1, it being understood that at most three of U1, U2, U3 and U4 can be N at the same time; V1 is N or CR5, V2 is N or CR6, V3 is N or CR7 and V4 is N or CH, it being understood that at most two of V1, V2, V3 and V4 can be N at the same time; R1 is H, cyano, hydroxy or alkoxy; R2 is H, hydroxy or alkoxy; R3 is H, cyano, hydroxy, alkoxy or carboxamido; R4 is H or alkoxy; R5 is H, hydroxy or halogen; R6 is H, hydroxy or halogen; R7 is H; the dotted line “______” represents a bond or is absent; W represents CH or N when the dotted line “______” is a bond, or W represents CH2 when the dotted line “______” is absent; X represents CH or N; and Q represents O or S; and salts thereof.
公开/授权文献
- US09527867B2 Antibacterial biaromatic derivatives 公开/授权日:2016-12-27
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