Methods and systems for enhanced 2-wire and 3-wire WLAN Bluetooth coexistence solution may include determining whether adaptive frequency hopping is active in a Bluetooth communication device. If the adaptive frequency hopping is active, handshaking with a collocated non-Bluetooth communication device may be disabled. The collocated non-Bluetooth communication device may be a wireless local area network communication device. If the adaptive frequency hopping is inactive, handshaking with the collocated non-Bluetooth communication device may be enabled. If the adaptive frequency hopping is inactive, the Bluetooth communication device may initiate handshaking prior to transmitting data. If the adaptive frequency hopping is inactive, the Bluetooth communication device may also respond to the handshaking initiated by the collocated non-Bluetooth communication device. The handshaking may be executed via a 2-wire Bluetooth/WLAN coexistence interface or a 3-wire Bluetooth/WLAN coexistence interface.