Invention Application
- Patent Title: VISTA Antagonist and Methods of Use
- Patent Title (中): VISTA拮抗剂和使用方法
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Application No.: US14686422Application Date: 2015-04-14
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Publication No.: US20160083472A1Publication Date: 2016-03-24
- Inventor: Randolph J. Noelle , Li Wang , Thomas Broughton , Lorenzo F. Sempere , Janet Louise Lines
- Applicant: Randolph J. Noelle , Li Wang , Thomas Broughton , Lorenzo F. Sempere , Janet Louise Lines
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395 ; A61K39/00 ; C07K16/30 ; A61K45/06
Abstract:
The present invention is directed to synergic or additive therapies comprising the administration of a VISTA antagonist and a PD-1, PD-L1 or POD-L3 antagonist; or the combination of a VISTA agonist and a -1, PD-L1 or POD-L3 agonist which combinations respectively elicit an additive or synergistic effect at promoting T cell immunity or inhibiting T cell immunity, i.e., CD4, CD8 or Th1 immunity. The agonists and antagonists may be in the same or separate compositions and may be administered together or separately administered in either order.
Public/Granted literature
- US20180237525A9 VISTA Agonist and Methods of Use Public/Granted day:2018-08-23
Information query
