This document provides fluid handling components. For example, this document relates to taper interface connections such as, but not limited to, luer taper interface connections used to couple fluid handling components in a medical or laboratory setting. In some embodiments, the threaded connection on the male portion of the taper interface is comprised of one or two opposing tabs, rather than a 360° collar like conventional luer lock fittings. As such, the taper interface components provided herein are readily manufacturable with a lower cost than conventional fittings that have a collar. In some embodiments, the taper interface components provided herein are configured for coupling by way of a quick connection technique.