An engine system is disclosed. The engine system may have an engine having an accessory end and a drive end opposite the accessory end. The engine system may also have a turbocharger arrangement located adjacent the accessory end. The turbocharger arrangement may be configured to receive exhaust from the engine and to deliver compressed air to the air cooling arrangement. Further, the engine system may have an air cooling arrangement located adjacent the accessory end and configured to deliver fresh air to the engine. In addition, the engine system may have a mixing duct extending from the accessory end to the drive end and configured to receive the exhaust from the turbocharger arrangement. The engine system may also have an after-treatment system located adjacent the drive end. The after-treatment system may be configured to receive the exhaust from the mixing duct and to discharge the exhaust to an ambient.