The present disclosure provides systems and methods for using two imaging modalities for imaging an object at two different resolutions. For example, the system may utilize a first modality (e.g., ultrasound or electromagnetic radiation) to generate image data at a first resolution. The system may then utilize the other modality to generate image data of portions of interest at a second resolution that is higher than the first resolution. In another embodiment, one imaging modality may be used to resolve an ambiguity, such as ghost images, in image data generated using another imaging modality.