发明申请
US20160096843A1 PYRAZOLO-PYRROLIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
有权
吡咯并吡啶-4-酮衍生物及其在治疗疾病中的应用
- 专利标题： PYRAZOLO-PYRROLIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
- 专利标题（中）： 吡咯并吡啶-4-酮衍生物及其在治疗疾病中的应用
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申请号： US14892628申请日： 2014-05-27
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公开(公告)号： US20160096843A1公开(公告)日： 2016-04-07
- 发明人: Jutta BLANK , Simona COTESTA , Vito GUAGNANO , Heinrich RUEEGER
- 申请人： Jutta BLANK , Simona COTESTA , Vito GUAGNANO , Heinrich RUEEGER
- 申请人地址： CH Basel
- 专利权人： NOVARTIS AG
- 当前专利权人： NOVARTIS AG
- 当前专利权人地址： CH Basel
- 优先权： EP13169448.1 20130528
- 国际申请： PCT/IB2014/061743 WO 20140527
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/444 ; A61K31/506 ; A61K31/4439
摘要：
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the pyrazolo-pyrrolidin-4-one derivatives, and their use as BET inhibitors for the treatment of conditions or diseases such as cancer. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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