Methods and apparatus for supporting reference signals for positioning measurements are disclosed. Methods include subframe configuration, subframe structures, measurement opportunities using a set of downlink subframes which are not all consecutive, handling of subframes containing reference signals and system signals such as synchronization signals, paging occasions and Multicast Broadcast Multimedia Service (MBMS), and related control signaling between a long term evolution (LTE) network and a wireless transmit/receive unit (WTRU). Moreover, methods to resolve allocation conflicts arising between positioning reference signals and other reference signals are disclosed.