Provided are methods for the treatment of various neural disorders including non-demyelinating neural disorders, such as Alzheimer's disease, as well as methods for the treatment of various autoimmune or immune-mediated disorders, such as scleroderma. Also provided are methods for restoring or improving one or more nerve functions, such as neural transmission, in a human with a neural disorder, such as a non-demyelinating neural disorder. Each of these methods comprise the administration of a serum composition obtained from a goat after challenge with an immunogen, in particular HIV or a lysate thereof.