Invention Application
- Patent Title: PROCESS FOR THE STEREOSELECTIVE PREPARATION OF A PYRAZOLE-CARBOXAMIDE
- Patent Title (中): 吡唑酰胺的立体选择性制备方法
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Application No.: US14892386Application Date: 2014-06-19
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Publication No.: US20160108001A1Publication Date: 2016-04-21
- Inventor: Raphael DUMEUNIER , Jilali KESSABI , Sebastian Volker WENDEBORN , Hannes NUSSBAUMER
- Applicant: SYNGENTA PARTICIPATIONS AG
- Applicant Address: CH Basel
- Assignee: SYNGENTA PARTICIPATIONS AG
- Current Assignee: SYNGENTA PARTICIPATIONS AG
- Current Assignee Address: CH Basel
- Priority: EP13173724.9 20130626
- International Application: PCT/EP2014/062936 WO 20140619
- Main IPC: C07D231/14
- IPC: C07D231/14 ; C07C239/20

Abstract:
The present invention relates to a process for the enantioselective preparation of the compound of formula (Ib), which process comprises a) reducing the (E)- or (Z)-form of a compound of formula (II), with an enantioselective reagent to a compound of formula (IIIa), and b) acylating the compound of formula (IIIa) with the compound of formula (IV), or c) coupling the compound of formula (IV) with the compound of formula (II), to give a compound of formula (V) and d) reducing compound of formula (V) in the presence of hydrogen, a catalyst and a chiral ligand, to the compound of formula (Ib).
Public/Granted literature
- US09637457B2 Process for the stereoselective preparation of a pyrazole-carboxamide Public/Granted day:2017-05-02
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