In a BOG treatment system, boil-off gas (BOG) discharged from a storage tank is compressed, most of the BOG is used as the fuel of vessel engines, and a remaining part of the BOG is liquefied by cold energy of BOG newly discharged from the storage tank and is returned to the storage tank, thereby efficiently utilizing the BOG. The BOG treatment system for a vessel includes a compressor compressing the BOG discharged from the storage tank; a medium pressure gas engine receiving at least a part of the BOG compressed by the compressor, as fuel; a heat exchanger exchanging heat between the remaining part of the BOG, which is not supplied to the medium pressure gas engine as fuel, and the BOG, which is discharged from the storage tank and is not compressed; and an expander decompressing the remaining part of the BOG cooled by the heat exchanger.