Invention Application
US20160115217A1 COMPOSITIONS OF HUMANIZED NOTCH FUSION PROTEINS AND METHODS OF TREATMENT
审中-公开
人源化融合蛋白的组合物和治疗方法
- Patent Title: COMPOSITIONS OF HUMANIZED NOTCH FUSION PROTEINS AND METHODS OF TREATMENT
- Patent Title (中): 人源化融合蛋白的组合物和治疗方法
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Application No.: US14844642Application Date: 2015-09-03
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Publication No.: US20160115217A1Publication Date: 2016-04-28
- Inventor: Jan Kitajewski , Carrie Shawber
- Applicant: Jan Kitajewski , Carrie Shawber
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Main IPC: C07K14/705
- IPC: C07K14/705
Abstract:
This invention provides a fusion protein comprising a signal peptide, an extracellular domain of human Notch receptor protein and an Fc portion of an antibody bound thereto. This invention also provides a method for treating a subject having a tumor, a method for inhibiting angiogenesis in a subject, a method for treating a subject having ovarian cancer, and a method for treating a subject having a metabolic disorder, comprising administering to the subject an amount of the above fusion protein effective to treat the subject. This invention further provides uses of the above fusion protein for the preparation of a pharmaceutical composition for the treatment of a subject having a tumor, for inhibiting angiogenesis in a subject, for treating a subject having ovarian cancer, and for treating a subject having a metabolic disorder.
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