发明申请
- 专利标题： SUBSTITUTED HETEROCYCLIC COMPOUNDS AS CRAC MODULATORS
- 专利标题（中）： 取代的杂环化合物作为CRAC调节剂
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申请号： US14899719申请日： 2014-06-20
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公开(公告)号： US20160145268A1公开(公告)日： 2016-05-26
- 发明人: Nageswara Rao IRLAPATI , Nilesh Raghunath KHEDKAR , Ravindra Babanrao JAPE , Rahul Shripad NANDURDIKAR , Zubair Abdul Wajid SHAIKH , Neelima SINHA , Venkata P. PALLE , Rajender Kumar KAMBOJ
- 申请人： LUPIN LIMITED
- 优先权： IN2105/MUM/2013 20130621; IN917/MUM/2014 20140320
- 国际申请： PCT/IB2014/062482 WO 20140620
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; C07D413/04 ; C07D265/36 ; C07D413/14 ; C07D413/12 ; C07D263/58 ; C07D417/04
摘要：
The invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine for the treatment of diseases, disorders associated with the modulation of calcium release-activated calcium (CRAC) channel. The invention also relates to pharmaceutical compositions containing such compounds in treating diseases disorders associated with calcium release-activated calcium (CRAC) channel modulators. wherein, ring D is Formula (a) or Formula (b): A and B, which may be same or different, are independently CR3 or N; Y is CR3 or N; L is selected from —NR2C(O)—, —C(O)NR2— and —NR2CRaRb—; Ra and Rb are independently hydrogen, halogen or substituted or unsubstituted alkyl; ring E is selected from the Formula (i) to (vii).
公开/授权文献
- US09725463B2 Substituted heterocyclic compounds as CRAC modulators 公开/授权日：2017-08-08
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