发明申请
- 专利标题： Broad-Spectrum Monoclonal Antibody Recognizing HA1 Domain of Hemagglutinin of Influenza Virus
- 专利标题（中）： 广谱单克隆抗体识别流感病毒血凝素的HA1结构域
-
申请号： US14781391申请日： 2014-04-02
-
公开(公告)号： US20160145320A1公开(公告)日： 2016-05-26
- 发明人: Yixin CHEN , Qingbing ZHENG , Rui LI , Chenguang SHEN , Shaojun KE , Wenxin LUO , Honglin CHEN , Ningshao XIA
- 申请人： XIAMEN UNIVERSITY
- 优先权： CN201310113101.5 20130402
- 国际申请： PCT/CN2014/074612 WO 20140402
- 主分类号： C07K16/10
- IPC分类号： C07K16/10 ; G01N33/569
摘要：
The invention relates to antibodies recognizing epitopes on HA1 domain of hemagglutinin (HA) protein of influenza virus, cell lines for producing the antibodies, and uses thereof. The antibodies according to the invention can specifically bind to HA1 domain of different HA subtypes and specifically bind to HA1 domain of hemagglutinin (HA) protein of H1 subtype (including seasonal H1N1 and 2009 pandemic H1N1) and H5 subtype of influenza viruses. Therefore, the invention also relates to vaccines or pharmaceutical compositions for preventing and/or treating infection of H1 subtype and H5 subtype influenza virus and/or a disease caused by the infection (e.g. influenza), comprising the antibodies according to the invention.
公开/授权文献
信息查询
