发明申请
US20160145334A1 NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST THE NOGO-66 RECEPTOR (NgR) AND USES THEREOF
审中-公开
去除NOGO-66受体（NgR）的单克隆抗体及其用途
- 专利标题： NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST THE NOGO-66 RECEPTOR (NgR) AND USES THEREOF
- 专利标题（中）： 去除NOGO-66受体（NgR）的单克隆抗体及其用途
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申请号： US14989532申请日： 2016-01-06
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公开(公告)号： US20160145334A1公开(公告)日： 2016-05-26
- 发明人: Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole Teusch
- 申请人： AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K39/395
摘要：
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.