发明申请
- 专利标题： RNA INTERFERENCE COMPOSITIONS AND METHODS FOR MALIGNANT TUMORS
- 专利标题（中）： RNA干扰组合物和恶性肿瘤的方法
-
申请号： US14979566申请日： 2015-12-28
-
公开(公告)号： US20160186182A1公开(公告)日： 2016-06-30
- 发明人: Yoshiro Niitsu , Kenjirou Minomi , Bharat Majeti , Jens Harborth , Li Wang , Jihua Liu , Yun Liu , Roger Adami , Wenbin Ying
- 申请人： Nitto Denko Corporation
- 优先权： JP2014-266198 20141226
- 主分类号： C12N15/113
- IPC分类号： C12N15/113
摘要：
This invention provides compositions for use in distributing active agents for treating a malignant tumor in a subject. The compositions contain RNAi molecules targeted to a human GST-π, along with RNAi molecules targeted to a human p21, and a pharmaceutically acceptable carrier. The carrier can include nanoparticles composed of an ionizable lipid, a structural lipid, one or more stabilizer lipids, and a lipid for reducing immunogenicity of the nanoparticles. This invention further provides methods for preventing or treating a malignant tumor by administering a therapeutically effective amount of an RNAi composition.
公开/授权文献
信息查询
IPC分类:
