Invention Application
- Patent Title: NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS II
- Patent Title (中): 新型神经营养因子1受体拮抗剂化合物II
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Application No.: US14913647Application Date: 2014-08-15
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Publication No.: US20160207930A1Publication Date: 2016-07-21
- Inventor: Haakan BLADH , Jakob FELDING , Ding ZHOU , Zhen-wei CAI , Morten Dahl SØRENSEN
- Applicant: LEO PHARMA A/S
- Applicant Address: DK Ballerup
- Assignee: LEO PHARMA A/S
- Current Assignee: LEO PHARMA A/S
- Current Assignee Address: DK Ballerup
- Priority: CNPCT/CN2013/081889 20130820
- International Application: PCT/EP2014/067494 WO 20140815
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K9/00 ; A61K31/4985

Abstract:
The invention relates novel NK1 receptor antagonists represented in formula A, wherein R1 and R2 independently are selected from the group consisting of (C1-4)alkyl, (C1-4)haloalkyl, (C1-4)alkoxy, CD3 or halogen; R3 is selected from the group consisting of hydrogen, (C1-4)alkyl, (C1-4)haloalkyl and (C1-4)hydroxyalkyl; R4 is selected from the group consisting of phenyl, 5-membered heteroaryl and 6-membered heteroaryl; R5 and R6 are independently selected from the group consisting of hydrogen, (C1-4)alkyl, (C1-4) hydroxyalkyl and (C1-4)haloalkyl and X and Y are independently selected from the group consisting of CH and N. The invention furthermore relates to intermediates for the preparation of said compounds, to their use in therapy, and to pharmaceutical compositions comprising said compounds.
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