Invention Application
- Patent Title: GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
- Patent Title (中): GLUCOSYLCERAMIDE SYNTHASE抑制剂
-
Application No.: US14835402Application Date: 2015-08-25
-
Publication No.: US20160207933A1Publication Date: 2016-07-21
- Inventor: Elyse BOURQUE , Mario CABRERA-SALAZAR , Cassandra CELATKA , Seng CHENG , Mary A. CROMWELL , Andrew GOOD , Bradford HIRTH , Katherine JANCSICS , John P. LEONARD , Lingyun LI , James LILLIE , Hanlan LIU , Elina MAKINO , John MARSHALL , Paul MASON , Markus METZ , Fazeela MORSHED , Thomas O'SHEA , Ronald SCHEULE , Renato SKERLJ , Bing WANG , Yibin XIANG , Zhong ZHAO
- Applicant: GENZYME CORPORATION
- Main IPC: C07D487/08
- IPC: C07D487/08 ; A61K31/439 ; A61K38/47 ; A61K31/551 ; C07D455/02 ; A61K31/46 ; C07D453/02 ; A61K31/506
Abstract:
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
Information query
