发明申请
US20160207994A1 MODULATORS OF IL-12 AND/OR IL-23 FOR THE PREVENTION OR TREATMENT OF ALZHEIMER'S DISEASE
审中-公开
IL-12和/或IL-23的调节剂用于预防或治疗阿尔茨海默病
- 专利标题： MODULATORS OF IL-12 AND/OR IL-23 FOR THE PREVENTION OR TREATMENT OF ALZHEIMER'S DISEASE
- 专利标题（中）： IL-12和/或IL-23的调节剂用于预防或治疗阿尔茨海默病
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申请号： US15000063申请日： 2016-01-19
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公开(公告)号： US20160207994A1公开(公告)日： 2016-07-21
- 发明人: Burkhard Becher , Frank Heppner
- 申请人： UNIVERSITAT ZURICH , CHARITE UNIVERSITATSMEDIZIN BERLIN
- 申请人地址： CH Zurich DE Berlin
- 专利权人： UNIVERSITAT ZURICH,CHARITE UNIVERSITATSMEDIZIN BERLIN
- 当前专利权人： UNIVERSITAT ZURICH,CHARITE UNIVERSITATSMEDIZIN BERLIN
- 当前专利权人地址： CH Zurich DE Berlin
- 优先权： EP11150090.6 20110104; EP11161991.2 20110412
- 主分类号： C07K16/24
- IPC分类号： C07K16/24 ; G01N33/50 ; A61K31/5377 ; A61K31/202 ; A61K38/17 ; C12N15/113
摘要：
The invention provides antibody against p40, IL-12 or IL-23 for the prevention or treatment of Alzheimer's disease. It further provides ligands to the pair of interleukin 12 or 23 and its specific receptor, specifically an antibody, an antibody fragment, an antibody-like-molecule, for the prevention or treatment of Alzheimer's disease. Similarly, siRNA, antisense or transcription factor modulators of gene expression of p19, p35, p40, IL-12R-β1, IL-12R-β2, and/or IL-23R for the prevention or treatment of Alzheimer's disease are provided.
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