发明申请
- 专利标题: THERAPEUTIC AGENT FOR CORNEAL EPITHELIAL DISORDER
- 专利标题(中): 角膜上皮疾病治疗药物
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申请号: US14914962申请日: 2014-08-27
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公开(公告)号: US20160208250A1公开(公告)日: 2016-07-21
- 发明人: Ayumi NAKAGAWA , Takeshi NAKAJIMA , Mitsuyoshi AZUMA
- 申请人: SENJU PHARMACEUTICAL CO., LTD.
- 申请人地址: JP Osaka-shi, Osaka
- 专利权人: SENJU PHARMACEUTICAL CO., LTD.
- 当前专利权人: SENJU PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: JP Osaka-shi, Osaka
- 优先权: JP2013-176996 20130828
- 国际申请: PCT/JP2014/072484 WO 20140827
- 主分类号: C12N15/113
- IPC分类号: C12N15/113 ; C12N5/079
摘要:
A therapeutic agent for a corneal epithelial disorder, containing a miR-203 inhibitor; an agent for promoting proliferation of corneal epithelial cells, containing a miR-203 inhibitor; a liquid culture medium for use in the manufacture of a corneal epithelial sheet, containing a miR-203 inhibitor; and a method for producing a corneal epithelial sheet, including the step of culturing corneal epithelial cells using a liquid culture medium containing a miR-203 inhibitor. According to the present invention, a therapeutic agent for a corneal epithelial disorder, an agent for promoting proliferation of corneal epithelial cells, a liquid culture medium for use in the manufacture of a corneal epithelial sheet, a method for producing a corneal epithelial sheet, including the step of culturing corneal epithelial cells using the liquid culture medium, and a method for treating a corneal epithelial disorder can be provided. The present inventors have also found that not only the above effects are exhibited by inhibiting miRNA richly contained in tears, but also the agent specifically acts on eye surfaces, so that the present invention can be expected to show high safety.
公开/授权文献
- US09562231B2 Therapeutic agent for corneal epithelial disorder 公开/授权日:2017-02-07
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