Invention Application
US20160222022A1 3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
审中-公开
3-ARYL-4-AMIDO-BICYCLIC [4,5,0]氢氧化物作为HDAC抑制剂
![3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS](/docs/US/2016-08-04/US20160222022A1/abs.jpg.600x600.jpg)
- Patent Title: 3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
- Patent Title (中): 3-ARYL-4-AMIDO-BICYCLIC [4,5,0]氢氧化物作为HDAC抑制剂
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Application No.: US15013816Application Date: 2016-02-02
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Publication No.: US20160222022A1Publication Date: 2016-08-04
- Inventor: Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Heather Davis , Aleksandra Rudnitskaya , David Lancia, JR. , David S. Millan , Matthew W. Martin
- Applicant: Forma Therapeutics, Inc.
- Main IPC: C07D493/08
- IPC: C07D493/08 ; C07D267/14 ; C07D413/14 ; C07D413/06
![3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS](/abs-image/US/2016/08/04/US20160222022A1/abs.jpg.150x150.jpg)
Abstract:
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
Public/Granted literature
- US10239845B2 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors Public/Granted day:2019-03-26
Information query
