发明申请
- 专利标题: RORgamma MODULATORS
- 专利标题(中): RORGAMMA调制器
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申请号: US15022673申请日: 2014-09-18
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公开(公告)号: US20160229844A1公开(公告)日: 2016-08-11
- 发明人: T. G. Murali Dhar , Jingwu Duan , Hua Gong , Bin Jiang , Zhonghui Lu , David S. Weinstein
- 申请人: BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址: US NJ Princeton
- 专利权人: BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人: BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人地址: US NJ Princeton
- 国际申请: PCT/US2014/056197 WO 20140918
- 主分类号: C07D417/06
- IPC分类号: C07D417/06 ; C07D401/06 ; C07D401/12 ; C07D413/14 ; C07D215/58 ; C07D413/06
摘要:
Described are RORγ modulators of the formula (I), or pharmaceutically acceptable salts thereof, wherein all substituents are defined herein. The invention includes stereoisomeric forms of the compounds of formula I, including stereoisomerically-pure, scalemic and racemic form, as well as tautomers thereof. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
公开/授权文献
- US09725443B2 RORγ modulators 公开/授权日:2017-08-08
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