发明申请
US20160237121A1 COMPOUNDS THAT BIND TO HUMAN IMMUNODEFICIENCY VIRUS REV RESPONSE ELEMENT
审中-公开
与人体免疫缺陷病毒感染反应单元有关的化合物
- 专利标题： COMPOUNDS THAT BIND TO HUMAN IMMUNODEFICIENCY VIRUS REV RESPONSE ELEMENT
- 专利标题（中）： 与人体免疫缺陷病毒感染反应单元有关的化合物
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申请号： US15031232申请日： 2014-10-23
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公开(公告)号： US20160237121A1公开(公告)日： 2016-08-18
- 发明人: Yun-Xing Wang , Ping Yu
- 申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY TH E SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICE
- 申请人地址： US MD Bethesda
- 专利权人： The United States of America, as represented by th e Secretary, Dept. of Health and Human Services
- 当前专利权人： The United States of America, as represented by th e Secretary, Dept. of Health and Human Services
- 当前专利权人地址： US MD Bethesda
- 国际申请： PCT/US2014/061975 WO 20141023
- 主分类号： C07K14/00
- IPC分类号： C07K14/00 ; A61K51/08 ; A61K45/06 ; A61K49/14 ; A61K47/48 ; A61K38/17 ; G01N33/569 ; A61K49/00
摘要：
Disclosed herein are compounds (such as peptides or peptide mimetics) that bind to HIV RRE RNA. In some examples, the compounds inhibit (for example, decrease) binding of Rev to the RRE RNA. In some embodiments, the compounds include two moieties, each of which bind to one of the Rev binding sites in the RRE. In some examples, the moieties include peptides or small molecules. In some examples, the peptides include an arginine-rich motif. The RRE binding compounds may be further linked to a detectable label or cargo moiety. Also disclosed are methods of treating or inhibiting HIV including administering one or more of the disclosed compounds to a subject.