The present disclosure provides a method and a device for eliminating inter-system neighbor cell interference. The method includes the following steps: receiving, by a first wireless access device, a first interference indication, where the first interference indication is sent by a first terminal when the first terminal detects that neighbor cell interference caused by a second terminal to the first terminal is greater than or equal to a preset threshold, the first interference indication is used for indicating that the first terminal suffers the neighbor cell interference; sending, by the first wireless access device, a decreasing interference indication to a second wireless access device corresponding to the second terminal when determining that the first terminal suffers the neighbor cell interference from the second terminal, so that the second wireless access device executes a decreasing interference strategy to eliminate neighbor cell interference between the first terminal and the second terminal.