发明申请
- 专利标题： ONCOLYTIC HSV VECTOR
- 专利标题（中）： ONCOLYTIC HSV矢量
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申请号： US15032958申请日： 2014-10-28
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公开(公告)号： US20160250267A1公开(公告)日： 2016-09-01
- 发明人: Hiroaki UCHIDA , Justus B. COHEN , Joseph C. GLORIOSO, III , Paola GRANDI
- 申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- 国际申请： PCT/US2014/062676 WO 20141028
- 主分类号： A61K35/763
- IPC分类号： A61K35/763 ; C12N7/00
摘要：
The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and one or more copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.
公开/授权文献
- US10201575B2 Oncolytic HSV vector 公开/授权日：2019-02-12
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