The present invention provides a driving method and a driving circuit of a display panel and a display device. The display panel comprises: gate lines and data line and pixel units, the data lines comprises: first data lines and second data lines, and a first predetermined number of first data line(s) and a second predetermined number of second data line(s) are alternately arranged. The driving method comprises a step of: scanning the gate lines in turn, wherein when scanning one gate line, a data voltage signal is applied to the first data lines or the second data lines. Compared to the driving method in the prior art, the driving method provided by the present invention allows lower power consumption of the OLED panel when display at the same brightness is achieved.