- 专利标题： TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
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申请号： US15153685申请日： 2016-05-12
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公开(公告)号： US20160256448A1公开(公告)日： 2016-09-08
- 发明人: Kenneth W. BAIR , Torsten HERBERTZ , Goss S. KAUFFMAN , Katherine J. KAYSER-BRICKER , George P. LUKE , Matthew W. MARTIN , David S. MILLAN , Shawn E.R. SCHILLER , Adam C. TALBOT
- 申请人： Forma Therapeutics, Inc.
- 主分类号： A61K31/4709
- IPC分类号： A61K31/4709 ; A61K31/5377 ; A61K31/517 ; A61K31/506 ; A61K31/519 ; A61K31/496 ; A61K31/501 ; A61K31/47 ; A61K31/4745 ; A61K31/4725 ; A61K31/52 ; A61K45/06 ; A61K31/497
摘要：
The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R1, R2, R5, and R8 are as described herein.
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