A capacitive touch screen of e.g., a mobile communications device such as a smart phone or tablet is operated by producing a capacitance map of capacitance values for the screen, wherein the capacitance values are indicative of locations of the screen exposed to touch by a user, and by identifying locations of the screen exposed to touch by a user by comparing the capacitance values against settings of sensing thresholds. Descriptor processing is applied to the capacitance map to extract a set of descriptors indicative of said screen being in one of a plurality of different operating conditions. A set of rules is applied to these descriptors to identify one of a plurality of different operating conditions, and selecting the setting of sensing thresholds as a function of the operating condition thus identified.