发明申请
US20160264538A1 C6-SPIRO IMINOTHIADIAZINE DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
有权
C6-SPIRO三嗪二氧化物作为BACE抑制剂，组合物及其使用
- 专利标题： C6-SPIRO IMINOTHIADIAZINE DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
- 专利标题（中）： C6-SPIRO三嗪二氧化物作为BACE抑制剂，组合物及其使用
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申请号： US14653671申请日： 2013-12-16
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公开(公告)号： US20160264538A1公开(公告)日： 2016-09-15
- 发明人: Jared N. Cumming , Jack D. Scott, JR. , Andrew W. Stamford , Ulrich Iserloh , Santhosh Francis Neelamkavil , Pengcheng Patrick Shao , Jonathan E. Wilson
- 申请人： Jared N. CUMMING , Jack D. SCOTT , Andrew W. STAMFORD , Ulrich ISERLOH , Santhosh Francis NEELAMKAVIL , Pengcheng Patrick SHAO , Jonathan E. WILSON , MERCK SHARP & DOHME CORP.
- 国际申请： PCT/US2013/075400 WO 20131216
- 主分类号： C07D285/24
- IPC分类号： C07D285/24 ; C07D471/04 ; C07D417/12 ; C07D513/10 ; C07D519/00
摘要：
In its many embodiments, the present invention provides certain C5-spiro iminothiadiazine dioxide compounds, including compounds Formula (I): (structurally represented) or tautomers thereof, and pharmaceutically acceptable salts of said compounds, wherein R1, R2, R3, X, Y, s, ring A, RA, m, -L1-, and RL are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed:
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