发明申请
- 专利标题: DISACCHARIDE INTERMEDIATE AND SYNTHESIS METHOD THEREOF
- 专利标题(中): 不同的中间体及其合成方法
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申请号: US15036390申请日: 2014-04-28
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公开(公告)号: US20160264609A1公开(公告)日: 2016-09-15
- 发明人: Yanghui Guo , Junhui Zhou , Qingfeng Cai , Hegeng Wei , Hua Bai , Fei Long , Yue Zhang , Yingqiu Wu
- 申请人: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- 申请人地址: CN Zhejiang
- 专利权人: Zhejiang Hisun Pharmaceutical Co., Ltd.
- 当前专利权人: Zhejiang Hisun Pharmaceutical Co., Ltd.
- 当前专利权人地址: CN Zhejiang
- 优先权: CN201310571340.5 20131114
- 国际申请: PCT/CN2014/076359 WO 20140428
- 主分类号: C07H11/00
- IPC分类号: C07H11/00 ; C07H17/04
摘要:
The present invention relates to a disaccharide intermediate and a synthesis method thereof, relates to the chemical pharmaceutical field, and more specifically relates to a method for preparing a disaccharide segment of a key intermediate for chemically synthesizing heparin and heparinoid compounds. Disclosed are a new disaccharide intermediate and three methods for synthesizing the disaccharide intermediate, that is, compounds of a formula (4) and glucopyranose protected by different anomeric carbon are made to react in the presence of an active agent, to obtain the disaccharide intermediate. According to the technical solutions of the present invention, synthetic raw materials are easy to obtain, have a mild reaction condition, and are suitable for industrialized production.
公开/授权文献
- US10287309B2 Disaccharide intermediate and synthesis method thereof 公开/授权日:2019-05-14