Described are a system and method of automatically maintaining a personal inventory of a medication. The method includes receiving data associated with an identification code mapped to a personal inventory of a medication for a patient, the type of the medication and an identity of the patient. An updated quantity of the personal inventory based on a quantity of the medication in the personal inventory and a quantity of dispensed or expired medication in the personal inventory is determined. The updated quantity is compared to a threshold quantity and a notification of a requirement for replenishment of the personal inventory is transmitted if the updated quantity is less than the threshold quantity. Any facility, such as a school or daycare center, that maintains one or more personal inventories of medication and has a caregiver to dispense the medication can benefit from the method.