A system and method are disclosed for providing electrically isolated communications between two USB2 devices. Two isolating eUSB2 repeaters are utilized to implement a digital isolation barrier between the two USB2 devices. The isolating eUSB2 repeaters are configured to broker isolated communications between the two USB2 devices using a modified eUSB2 protocol that allows the two isolating eUSB2 repeaters to interoperate across the isolating barrier. The modified eUSB2 protocol allows the two isolating eUSB2 repeaters to broker isolating communications on behalf of the USB2 devices without the use of an accurate clock signal. The modified eUSB2 protocol utilized by the isolating eUSB2 repeaters is configured in particular to support certain end-of-packet translations between USB2 data and the modified eUSB2 protocol, management of certain USB2 bus state transitions and assignment of roles to the two isolating eUSB2 repeaters.