Adjustable catheter including an elongate tubular shaft having a proximal portion, a distal portion, and a length therebetween. The elongate tubular shaft has a guidewire lumen defined therein extending along at least the distal portion of elongate tubular member and further has at least one pressure lumen defined therein extending along at least a section of the length of the elongate tubular shaft. The at least one pressure lumen having a proximal end and a closed distal end. A fluid adaptor is in fluid communication with the at least one pressure lumen. The catheter has a stiffness profile and a flexibility profile along a length there of and at least one of the stiffness profile and the flexibility profile selectively adjustable upon introduction of a pressurizing fluid into the at least one pressure lumen.