发明申请
US20160272707A1 VSTM5 ANTIBODIES, AND USES THEREOF FOR TREATMENT OF CANCER, INFECTIOUS DISEASES AND IMMUNE RELATED DISEASES
审中-公开
VSTM5抗体及其用于治疗癌症，感染性疾病和免疫相关疾病的用途
- 专利标题： VSTM5 ANTIBODIES, AND USES THEREOF FOR TREATMENT OF CANCER, INFECTIOUS DISEASES AND IMMUNE RELATED DISEASES
- 专利标题（中）： VSTM5抗体及其用于治疗癌症，感染性疾病和免疫相关疾病的用途
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申请号： US15021239申请日： 2014-09-11
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公开(公告)号： US20160272707A1公开(公告)日： 2016-09-22
- 发明人: Zurit LEVINE , Galit ROTMAN , Liat DASSA , Ofer LEVY , Gad S. COJOCARU , Amir TOPORIK , Yossef KLIGER , Andrew POW , Spencer LIANG
- 申请人： COMPUGEN LTD.
- 国际申请： PCT/IL2014/050814 WO 20140911
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K31/664 ; C07K16/30 ; A61K39/00 ; A61K39/395 ; A61K45/06
摘要：
The present invention relates to VSTM5-specific antibodies, antibody fragments, and VSTM5 polypeptides, conjugates and compositions comprising same, for modulating (antagonizing or agonizing) one or more of the effects of VSTM5 expression on immunity. More specifically, the present invention relates to VSTM5-specific antibodies, antibody fragments, and VSTM5 polypeptides, conjugates and compositions comprising same for treating and aiding in the diagnosis of cancer, infectious diseases and immune related diseases, e.g., those associated with aberrant (higher or lower than normal) VSTM5 expression by diseased and/or immune cells and/or aberrant (increased or reduced) VSTM5-mediated effects on immunity.
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