The invention discloses an encryption processing device and a method capable of defending differential power analysis attack. In the encryption processing device provided by an embodiment of the invention, a SecMasking unit is achieved in a structure that a universal random masking technique services as a basis; a SecPrepare unit is achieved in a structure that a bitwise XOR device services as a basis; and a SecSbox unit is achieved in a mode that table look-up results are updated longitudinally and transversely in real time on the basis of a random masking technique. According to the encryption processing device and method, work power consumption of a cryptographic operation equipment circuit can have no relation with operation data and calculation operations. In addition, the encryption processing device and method can be widely used for encrypting and decrypting operation cryptographic equipment needing high safety performance.