Invention Application
US20160280649A1 ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFNalpha RESPONSES
审中-公开
作为IL-12，IL-23和/或IFNα应答的调节剂的ALKYL-酰胺取代的吡啶化合物
- Patent Title: ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFNalpha RESPONSES
- Patent Title (中): 作为IL-12，IL-23和/或IFNα应答的调节剂的ALKYL-酰胺取代的吡啶化合物
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Application No.: US15034915Application Date: 2014-01-16
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Publication No.: US20160280649A1Publication Date: 2016-09-29
- Inventor: Ryan M. MOSLIN , David S. WEINSTEIN , Stephen T. WROBLESKI , Yanlei ZHANG , John S. TOKARSKI , Michael E. MERTZMAN , Chunjian LIU
- Applicant: Bristol-Myers Squibb Company
- Priority: TW102140574 20131107; VE2013/1400 20131111; ARP130104090 20131117
- International Application: PCT/US2014/011769 WO 20140116
- Main IPC: C07D213/82
- IPC: C07D213/82 ; C07D417/12 ; C07D413/12 ; C07B59/00 ; C07D405/12 ; C07D401/12
Abstract:
Compounds having the following formula (I): or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα by acting on Tyk-2 to cause signal transduction inhibition.
Public/Granted literature
- US09663467B2 Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses Public/Granted day:2017-05-30
Information query
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